Quick info
3-CMC (clophedrone, 3-chloromethcathinone) and 4-CMC (clephedrone, 4-chloromethcathinone) are new psychoactive substances and belong to the synthetic cathinones of the amphetamine group. There is hardly any information available on risks, side effects and long-term consequences. It is assumed that 3-CMC and 4-CMC have a very high neurotoxic effect. The chemical structure is similar to that of 3-MMC and 4-MMC (mephedrone). 3-CMC and 4-CMC are often marketed on the Internet as a substitute for mephedrone.
The effect is described as similar to 3-MMC, but milder. Furthermore, 3-CMC and 4-CMC have a stimulating, uplifting, anxiolytic, disinhibiting, slightly euphoric, concentration- and performance-enhancing and libido-increasing effect. An increased urge to talk and a pronounced empathy have also been reported (although to a lesser extent than with MDMA).
Onset of action:
Snorted: after 10 - 30 minutes
Swallowed: after 30 - 60 minutes
Duration of action:
Snorted: 1 - 2 hours
Swallowed: 2 - 4 hours
Snorted:
light: 20 - 40 mg
medium: 40 - 80 mg
strong: 80 - 100 mg
Swallowed:
light: 30 - 60 mg
medium: 60 - 100mg
strong: 100 - 180 mg
Little is known about intravenous, rectal, and inhalation use. These forms of use should be avoided. If you do try any of these forms of use, use as low a dose as possible.
Forms of appearance
White to brownish crystalline powder or crystals
Craving can be very pronounced when consuming 3-CMC and 4-CMC, and the potential for dependence is therefore high.
3-CMC and 4-CMC are very likely to be highly neurotoxic and there is a risk of brain damage. Other side effects can include dehydration (lack of fluid in the body), increased blood pressure, suppression of bodily functions (hunger, thirst and urination), nausea, paranoia, psychotic phases (with high doses), strong craving, constriction of blood vessels (high risk with intravenous consumption), cardiovascular problems, circulatory problems (cold hands and feet), sexual dysfunction, depressive moods and listlessness.
3-CMC and 4-CMC are new psychoactive substances. To date, nothing is known about their exact mechanisms of action, toxicity and possible long-term effects. The current state of knowledge is based almost exclusively on reports from users. Due to the strong craving (irresistible and uncontrollable desire to consume), especially when snorting or smoking the substance, there is a risk that users will add too quickly and the side effects will predominate.
Since 2023, cathinones such as 3-CMC and 4-CMC have become more popular again and are increasingly being accepted in drug checking offers in Switzerland. The analysis results show that up to 75% of these samples contained synthesis by-products or (additional) ingredients other than the expected active ingredient. If you decide to use it, it is therefore important to have the substance tested first in a drug checking service and/or to test a small amount first.
LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.
Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.
In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.